Salmo, it's really not that bad... All you do is decide who is more likely to do better this weekend, compared to how their both predicted to do.

Vegas predicts Seahawks will win by 3 this week -- on the road, vs. Indianapolis. Vegas also predict SF will win by 6.5 -- at home vs. the Texans (ignore why they do .5).

Now all you have to decide is -- well, who will OVERACHIVE the most vs. these expectations? Or, in the case they both underachieve their expectations, who will do so by the least amount? The spread just makes it much more of a toss up each week, so intuition, coin flipping, or witchcraft are fine approaches here.
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The charm of fishing is that it is the pursuit of what is elusive but attainable, a perpetual series of occasions for hope. -John Buchan