Sitka has its good points but I like to get away from the people/commerce/touristy thing. Sitka reminds me too much of Ilwaco, WA. Just my opinion.
For me, SE AK for Yakutat & Cordova and SW AK for Cold Bay & King Cove are my favorites for the overall experience and the "Do it yourselfer". Rivers and salt. Fewer Kings but enough Silvers and Steelhead to damn near move there for. Enough Kings to keep ya happy. Also plenty of Chums, Pinks, Dollies, Rainbows and even Sockeyes. In the salt, enough Halibut and Tanners....I gotta get the family to move there...Best day I had up there this year was 68 silvers landed and countless #s of the other salmonids. Last trip I made this Sept was 6 plane rides, a boat trip (100' F/V), 14 nights for <$1500, but I can get by cheap. I go for the experience, not the meat, and just knowing that it still exists gets me through our fishing here in WA.