(CNN)Alex Acosta's decision as a US attorney in Florida to let Jeffrey Epstein avoid federal charges of sex trafficking nearly a decade ago has shadowed the Trump administration's labor secretary but now it may cost him his job.

Democrats, including House Speaker Nancy Pelosi, are calling for his resignation following the two count indictment announced Monday by prosecutors with the US Attorney's Office for the Southern District of New York accusing Epstein of sex trafficking in New York and Palm Beach, Florida from 2002 to 2005. Epstein, 66, pleaded not guilty to the new charges and faces as much as 45 years in prison if convicted.